Charlie Bennett is back! We start by chatting about the joys and challenges of hosting Nanovation. Then, within the context of the movie Terminator Genisys, which is truly awful, we discuss self-replicating nanomachines. We overview their original articulation, the scientific arguments for and against their ultimate realization, and how, in the near-term, biology is far more likely to get us. (Recorded on June 7, 2016.)